MICROENVIRONMENTAL STIFFNESS ENHANCES GLIOMA CELL PROLIFERATION BY STIMULATING EPIDERMAL GROWTH FACTOR RECEPTOR SIGNALING.

Microenvironmental stiffness enhances glioma cell proliferation by stimulating epidermal growth factor receptor signaling.

mitigated gall The aggressive and rapidly lethal brain tumor glioblastoma (GBM) is associated with profound tissue stiffening and genomic lesions in key members of the epidermal growth factor receptor (EGFR) pathway.Previous studies from our laboratory have shown that increasing microenvironmental stiffness in culture can strongly enhance glioma ce

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